An Autonomous Body under Ministry of Health and Family Welfare, Govt. of India

Faculty and Staff

Dr. Subhadip Hajra Senior Scientific Officer-II

Department: Cancer Research

Education

Academic Summary

  • Senior Scientific Officer, Grade II (2018) at Department of Cancer Chemoprevention, Chittaranjan National Cancer Institute, West Bengal, India.
  • Young Scientist (2014-2018) at Dept. of Cancer Chemoprevention, Chittaranjan National Cancer Institute, West Bengal, India.
  • Ph.D in Life Science (2012) at Dr. Hari Singh Gour Central University, Sagar, M.P. India.
  • M.Sc. in Microbiology (2007) at Jiwaji University, Gwalior. M.P. India.
  • B.Sc in Microbiology (2005) at Vidyasagar University, West Bengal, India.

Contact details: Tel. 91-33-2476-5101 (ext-316).
Email: dip.microworld@gmail.com; subhadiphajra@cnci.ac.in

The research theme in my lab relates to modulation of Cancer Stem cell division and Regulation of oncogenic hallmarks of KRAS mutated colorectal cancer cells by natural compound/s to restrict the drug resistance and recurrence of Breast and Colorectal cancer. 

List of Publications: Follow Google Scholar Link https://scholar.google.com/citations?hl=en&user=7gilq1wAAAAJ&view_op=list_works&sortby=pubdate

  • Ghosh R, Bhowmik A, Biswas S, Samanta P, Sarkar R, Pakhira S, Mondal M, Hajra S, Saha P. 2025. Natural flavonoid Orientin restricts 5-Fluorouracil induced cancer stem cells mediated angiogenesis by regulating HIF1α and VEGFA in colorectal cancer. Mol. Med. 31: 85.
  • Biswas S, Mondal M, Pakhira S, Ghosh R, Samanta P, Basu J, Bhowmik A, Hajra S, Saha P. 2025. Attenuation of paclitaxel-induced toxicities by polyphenolic natural compound rutin through inhibition of apoptosis and activation of NRF2/ARE signaling pathways. Food. Chem. Toxicol; 200:115408.
  • Dutta Gupta Y, Sarkar R, Bhowmik A, Bag N, Hajra S, Das S, Bhandary S. 2025. Functionalized Mesoporous Silica Nanoparticles for the Delivery of 3,3'-diindolylmethane to Triple-negative Breast Cancer Cells. Nanoscience & Nanotechnology-Asia; 15:3E22106812373327.
  • Sarkar R, Biswas S, Ghosh R, Samanta P, Pakhira S, Mondal M, Gupta YD, Bhandary S, Saha P, Bhowmik A, Hajra S. 2024. Exosome-sheathed porous silica nanoparticle-mediated co-delivery of 3,3′-diindolylmethane and doxorubicin attenuates cancer stem cell-driven EMT in triple negative breast cancer. J. Nanobiotechnol. 22(1): 285.
  • Samanta P, Ghosh R, Pakhira S, Mondal M, Biswas S, Sarkar R, Bhowmik A, Saha P, Hajra S. 2024. Ribosome biogenesis and ribosomal proteins in cancer stem cells: a new therapeutic prospect. Mol. Biol. Rep. 51(1):1016.
  • Chakravarti M, Bera S, Dhar S, Sarkar A, Choudhury PR, Ganguly N, Das J, Sultana J, Guha A, Biswas S, Das T, Hajra S, Banerjee S, Baral R, Bose A. 2024. Neem Leaf Glycoprotein Disrupts Exhausted CD8+ T-Cell–Mediated Cancer Stem Cell Aggression. Mol. Cancer Res. 22(8): 759-778.
  • Pakhira S, Samanta P, Ghosh R, Mondal M, Biswas S, Sarkar R, Bhowmik A, Hajra S, Saha P. 2024. Current Understanding on Impact of Kirsten Rat Sarcoma Viral Oncogene Mutation on Colorectal Cancer: A Review. J. Curr. Oncol. Trends. 1(1): 8-13.
  • Ghosh R, Biswas S, Samanta P, Sarkar R, Pakhira S, Mondal M, Bhowmik A, Hajra S, Saha P. 2024. Targeting Cancer Stem Cells by Natural Compounds in Combination with Conventional Chemotherapy: An Ideal Strategy for Combating Cancer Recurrence. J. Curr. Oncol. Trends. 1(1): 14-21.
  • Pal A, Ray R, Chouni A, Hajra S, Paul S. 2024. Novel wild edible mushroom Astraeus hygrometricus (Pers.) Morgan induces robust apoptosis on human acute lymphoblastic leukemia cells through RONS-subsisted mitochondria. J. Trad. Chinese Med. Sci. 11(1): 67-77.
  • Samanta P, Bhowmik A, Biswas S, Sarkar R, Ghosh R, Pakhira S, Mondal M, Sen S, Saha P, Hajra S. 2023. Therapeutic effectiveness of anticancer agents targeting different signaling molecules involved in asymmetric division of cancer stem cell. Stem Cell Rev. Rep. 19 (5): 1283-1306.
  • Ghosh R, Samanta P, Sarkar R, Biswas S, Saha P, Bhowmik A, Hajra S. 2022. Targeting HIF-1α by natural and synthetic compounds: a promising approach for anti-cancer therapeutics development. Molecules. 27 (16): 5192.
  • Bhowmik A, Biswas S, Hajra S, Saha P. 2021. In silico validation of potent phytochemical orientin as inhibitor of SARS-CoV-2 spike and host cell receptor GRP78 binding. Heliyon. 7(1):e05923.
  • Patra AR, Hajra S, Baral R, Bhattacharya S. 2020. Use of selenium as micronutrients for future anticancer drug: a review. The Nucleus. 63:107-118.
  • Hajra S, Patra AR, Basu A, Saha P, Bhattacharya S. 2018. Indole-3-Carbinol (I3C) enhances the sensitivity of murine breast adenocarcinoma cells to doxorubicin (DOX). Chem. Biol. Interact. 290:19-36.
  • Hajra S, Patra AR, Basu A, Bhattacharya S. 2018. Prevention of doxorubicin (DOX)-induced genotoxicity and cardiotoxicity by indole-3-carbinol (I3C). Biomed. Pharmacother. 101: 228-243.
  • Patra AR, Roy SS, Basu A, Bhuniya A, Bhattacharjee A, Hajra S, Hossion SK, Baral R, Bhattacharya S. 2018. Design and synthesis of coumarin-based organoselenium. Scientific Rep. 8: 2194.
  • Hajra S, Basu A, Roy SS, Patra AR, Bhattacharya S. 2017. Attenuation of doxorubicin-induced cardiotoxicity by 3,3’-diindolylmethane (DIM). Free Radic. Res. 51(9-10): 812-827.
  • Basu A, Bhattacharjee A, Hajra S, Samanta A, Bhattacharya S. 2016. Ameliorative effect of an oxovanadium (IV) complex. Redox Report. 22(6):377-387.
  • Patra AR, Roy SS, Basu A, Hajra S, Biswas J, Bhattacharya S. 2016. Enhancement of therapeutic index of carboplatin. J. Carcinog. P- S261.
  • Pandey P, Mehta A, Hajra S. 2016. Immunomodulatory activity of Ruta graveolens. Int. J. Pharm. Sci. 8(11): 332-336.
  • Pandey P, Mehta A, Hajra S, Mehta P. 2016. Antimicrobial potential of Ruta graveolens. Food Pharma Inter. 1(1): 38-40.
  • Ahirwal L, Singh S, Hajra S, Mehta A. 2013. Antioxidant potential of Gymnema sylvestre. Int. J. Pharm. Sci. Rev. Res. 19(1): 87-91.
  • Hajra S, Mehta A, Pandey P. 2012. Immunostimulating activity of Swietenia mahagoni. Int. J. Pharm. Sci. 4(1): 442-445.
  • Hajra S, Mehta A, Pandey P. 2012. Anthelmintic activity of Swietenia mahagoni. Int. J. Pharm. Sci. Rev. Res. 12(1): 111-113.
  • Hajra S, Mehta A, Pandey P. 2012. Antidiarrhoeal activity of Swietenia mahagoni. Int. J. Pharmacol. 8(5): 416-421.
  • Pandey P, Mehta A, Hajra S. 2012. Antidiarrhoeal activity of Ruta graveolens. Asian J. Pharm. Clin. Res. 5(4): 65-68.
  • Hajra S, Mehta A, Pandey P. 2011. Antimicrobial activity of Cassia fistula. J. Pharm. Res. 4(7): 2432-2435.
  • Pandey P, Mehta A, Hajra S. 2011. Antioxidant property of Ruta graveolens. J. Pharm. Res. 4(6): 1735-1737.
  • Pandey P, Mehta A, Hajra S. 2011. Antimicrobial activity of Ruta graveolens stem. J. Phytol. 3(3): 92-95.
  • Hajra S, Mehta A, Pandey P. 2011. Phenolic compounds of Swietenia mahagoni. Int. J. Pharm. Sci. 3(5): 431-434.
  • Mehta A, Pandey P, Mehta P, Hajra S. 2011. Immunomodulatory activity of Tinospora cordifolia. J. Pharm. Res. 4(12): 4727-4730.
  • Hajra S, Mehta A, Pandey P. 2011. Antioxidant and antidiabetic potential of Swietenia mahagoni. Int. J. Pharm. Res. Dev. 3(3): 180-186.
  • Hajra S, Mehta A, Pandey P. 2011. Free radical scavenging activity of Swietenia mahagoni oil. Int. J. Pharm. Phyto. Res. 5(1): 51-56.
  • Pandey P, Mehta A, Hajra S. 2010. Anthelmintic activity of Ruta graveolens. Int. J. Phyto. Rel. Ind. Med. Plants. 2(3): 240-243.
  • Pandey P, Mehta A, Hajra S. 2010. Antibacterial property of Citrus limon. Asian J. Exp. Biol. Sci. 189-191.
  • Pandey P, Mehta A, Hajra S. 2010. Antibacterial Property of Citrus limon. Inventi Rapid. 1(3): 1-3.
  • Hajra S, Mehta A, Pandey P. 2010. Antibacterial property of Mikania micrantha. Asian J. Exp. Biol. Sci. 166-168.

Book Published

  • Hajra S, Mehta A, Vyas SP (2012). Phyto-Pharmacological evaluation of seeds of Swietenia mahagoni. Lap Lambert Academic Publishing, Germany. pp. 1-453.

Book Chapters

  • Hajra S, Mehta A, Pandey P (2011). Role of Microbes in Agriculture. Manglam Publications, Delhi. pp. 1-16.
  • Mehta A, Hajra S, Pandey P (2011). Global warming and its impacts. Manglam Publications, Delhi. pp. 1-20.
  • Pandey P, Mehata A, Hajra S (2011). Plant secondary metabolites as a hepatoprotective drug. Sonali Publications, Delhi. pp. 228-247.
  • Alia A, Ahmad W, Mehta A, Hajra S (2011). Datura stramonium and its medicinal value. Sonali Publications, Delhi. pp. 76-83.
  • Pandey P, Mehta A, Hajra S (2011). Solid waste degradation by microorganisms. Sonali Publications, Delhi.
  • Mehta A, Hajra S, Mallick A (2010). Microbial Biodiversity and Nutrition. Discovery Publishing House, Delhi. pp. 133-141.

Principal Investigator Project Title Funding Agency
Dr. Subhadip Hajra Natural resources to increase the safety and efficacy of conventional chemotherapy by doxorubicin. Science and Engineering Research Board (Completed)
Regulation of crosstalk between EMT pathways and pathways maintaining anoikis resistant CSCs in triple negative breast cancer by exosome mediated co-delivery of 3,3'-diindolylmethane (DIM) and doxorubicin (DOX). Science and Engineering Research Board (Completed)
Inhibition of asymmetric division of triple negative breast cancer stem cells by porous silicon nanoparticle sheathed exosome mediated co-delivery of 3,3’-diindolylmethane and doxorubicin. Indian Council of Medical Research (Ongoing)
Dr. Subhadip Hajra (Co-PI) Exosome mediated co-delivery of natural flavonoid Orientin and 5-Fluorouracil for targeting colorectal cancer stem cells involved in angiogenic progression. Science and Engineering Research Board (Ongoing)

  1. Ms. Priya Samanta (CSIR-SRF)
  2. Ms. Shampa Pakhira (CSIR-SRF)
  3. Ms. Madhurima Biswas (DBT-JRF)
  4. Ms. Jhinuk Basu (ICMR-Project Research Scientist-II)

We are looking for highly motivated future doctoral/postdoctoral fellows who have their own source of funding and interested in phytochemicals/cancer stem cell research. If our research motivates you, please send an email to dip.microworld@gmail.com/ subhadiphajra@cnci.ac.in with your updated CV containing the names of three references along with a statement of purpose.