The department of Cancer Chemoprevention is focused to explore new potential natural compound/s present
in
our food/ beverage/ spices/ medicinal plants which are antioxidative, anti-proliferative and
proapoptotic in
nature. We evaluate the cytoprotective efficacy of these compounds to minimize the side effects of
chemotherapy as well as to increases the drug sensitivity. Our research team also focused in modulations
or
alterations of Cancer Stem Cells by natural compound when used in combination with conventional therapy.
These types of studies enable us to discover more effective strategies for prevention as well as therapy
to
reduce drug resistance and recurrence of cancer.
Dr. Prosenjit Saha
Senior Scientific Officer (Assistant Director Grade)- Link Profile
Dr. Subhadip Hajra
Senior Scientific Officer Grade‐II - Link Profile
| Sl No. |
Name of the Project |
Funded by |
Details |
| 1 |
Exosome mediated co-delivery of natural flavonoid Orientin and 5-Fluorouracil for
targeting
colorectal cancer stem cells involved in angiogenic progression. |
SERB |
5-Fluorouracil (5FU), a first-line medication for colorectal cancer, activates and
enriches
CSCs. Despite the fact that 5FU initially de-bulks the tumor mass, we showed that it
could
enhanced cancer stem cells (CSC) mediated angiogenesis. Therefore, in order to curb the
5FU-induced participation of CSCs in angiogenesis, a compelling therapeutic strategy of
combining 5FU with a non-toxic, potent natural flavonoid orientin has been implemented.
Orientin has restricted 5FU-induced enrichment of the CD44+/CD133+ CSC population.
Combinatorial treatment of 5FU and orientin significantly reduced the size and number of
colorectal cancer cells spheroids formation in comparison to only 5FU treatment. The
angiogenic factor HIF1α appears to be elevated after 5FU therapy. However, HIF1α
expression
was decreased as a result of combinatorial therapy. Furthermore, this combinatorial
treatment reduced the expression of VEGF, which is the downstream angiogenic regulator
of
HIF1α. These investigations will ultimately lead to the development of more potent
anti-colorectal cancer treatment plans by curbing angiogenesis. |
| 2 |
Regulation of crosstalk between EMT pathways and pathways maintaining anoikis resistant
CSCs
in triple negative breast cancer by exosome mediated co-delivery of
3,3'-diindolylmethane
(DIM) and doxorubicin (DOX). |
SERB |
|
| 3 |
Inhibition of asymmetric division of triple negative breast cancer stem cells by porous
silicon nanoparticle sheathed exosome mediated co-delivery of 3,3’ diindolyl methane and
doxorubicin |
ICMR |
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Name of the Fellow |
Funding Agency |
Projects |
Profile |
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