An Autonomous Body under the Ministry of Health and Family Welfare, Govt. of India

Faculty and Staff

Dr. Dona Sinha, PhD Senior Scientific Officer(Asst. Dir Gr.)

Department: Cancer Research

Education

PhD 2007, Chittaranjan National Cancer Institute, Jadavpur University, Kolkata

M.Sc. 1998 (Zoology, Cytology and Molecular Genetics), University of Burdwan 


B. Sc. Zoology (Hons) 1996, University of Burdwan


Post Doctoral Research:

ICMR-RA, Chittaranjan National Cancer Institute (2007-2009)

ICMR-DHR Overseas Fellowship for Senior Biomedical Scientists, Bernard J. Dunn School of Pharmacy, Shenandoah University, Fairfax, VA, USA (2023)

Our research group is focused to explore the following arenas of cancer biology-

ü  Health impact of environmental carcinogens

ü  Redox regulation and drug resistance

ü  Phenotypic plasticity

ü  Prognostic biomarkers

Google Scholar citations:

 

All

Since 2020

Citations

2084

1153

h-index

25

19

i10-index

33

26

 


Peer reviewed journals:


1.       Saha P, Das D, Behera SK, Bhatia D, Kumar S, Hajra S, Das D, Chakrabarti D, Sinha D*. Management of T cell responses by anesthetic drugs-propofol & isoflurane in perioperative breast cancer patients: A prospective hospital-based study. Ind J Med Res. 2024;160(5):489-500. doi: 10.25259/jmr_2382_23. 

2.       Chaudhuri R, Samanta A, Saha P, Ghosh S, Sinha D*. The Potential of Epigallocatechin Gallate in Targeting Cancer Stem Cells: A Comprehensive Review. Curr Med Chem. 2024; 31(32):5255-5280. doi: 10.2174/0109298673281666231227053726. Epub ahead of print.

3.       Fakhri S, Moradi SZ, Abbaszadeh F, Faraji F, Amirian R, Sinha D, McMahon EG, Bishayee A. Targeting the key players of phenotypic plasticity in cancer cells by phytochemicals. Cancer Metastasis Rev. 2024; 43 (1):261-292. doi: 10.1007/s10555-023-10161-8.

4.       Samanta A, Saha P, Johnson O, Bishayee A, Sinha D*. Dysregulation of delta Np63 alpha in squamous cell carcinoma and its therapeutic targeting. Biochim Biophys Acta Rev Cancer. 2024;1879(1):189034. doi: 10.1016/j.bbcan.2023.189034.

5.       Choudhary N, Bawari S, Burcher JT, Sinha D, Tewari D, Bishayee A. Targeting Cell Signaling Pathways in Lung Cancer by Bioactive Phytocompounds. Cancers. 2023; 15(15):3980. https://doi.org/10.3390/cancers15153980

6.       Datta S, Bishayee A, Sinha D*. Black tea bioactive phytoconstituents realign NRF2 for anticancer activity in lung adenocarcinoma. Front Pharmacol. 2023; 14:1176819. doi: 10.3389/fphar.2023.1176819. 

7.       Datta S, Ghosh S, Bishayee A, Sinha D*. Flexion of Nrf2 by tea phytochemicals: A review on the chemopreventive and chemotherapeutic implications. Pharmacol Res. 2022; 182:106319. https://doi.org/10.1016/j.phrs.2022.106319

8.       Prasad P, Singh SK, Ghosh S, Dutta S, Sinha D*. Influence of differential arsenic exposure on cellular redox homeostasis of exposed rural women of West Bengal. Environ Sci Pollut Res Int. 2022; 30(3):7836-7850. doi: 10.1007/s11356-022-22657-x.

9.       Datta S, Sinha D*. Low dose epigallocatechin-3-gallate revives doxorubicin responsiveness by a redox-sensitive pathway in A549 lung adenocarcinoma cells. J Biochem Mol Toxicol. 2022; 36(4): e22999. doi: 10.1002/jbt.22999.

10.   Saha P, Das A, Chatterjee N, Chakrabarti D, Sinha D*. Impact of anesthetics on oncogenic signaling network: a review on propofol and isoflurane. Fundam Clin Pharmacol. 2021; 36(1):49-71. doi: 10.1111/fcp.12732.

11.   Saha P, Datta S, Ghosh S, Samanta A, Ghosh P, Sinha D*. Bioengineering of Extracellular Vesicles: Exosome-Based Next-Generation Therapeutic Strategy in Cancer. Bioengineering. 2021; 8(10):139. https://doi.org/10.3390/bioengineering8100139

12.   Sinha D, Roy S, Saha P, Chatterjee N, Bishayee A. Trends in Research on Exosomes in Cancer Progression and Anticancer Therapy. Cancers. 2021; 13(2):326. https://doi.org/10.3390/cancers13020326

13.   Sinha D, Saha P, Samanta A, Bishayee A. Emerging Concepts of Hybrid Epithelial-to-Mesenchymal Transition in Cancer Progression. Biomolecules. 2020;10(11):1561. doi: 10.3390/biom10111561.

14.   Prasad P, Sarkar N, Sinha D*. Effect of low- and high-level groundwater arsenic on peripheral blood and lung function of exposed rural women. Regul Toxicol Pharmacol. 2020; 115:104684. doi: 10.1016/j.yrtph.2020.104684.

15.   Sinha D *, Prasad P. Health effects inflicted by chronic low-level arsenic contamination in groundwater: A global public health challenge. J Appl Toxicol. 2020;40(1):87–131. doi:10.1002/jat.3823

16.   Sarkar N, Das B, Bishayee A, Sinha D*. Arsenal of Phytochemicals to Combat Against Arsenic-Induced Mitochondrial Stress and Cancer. Antioxid Redox Signal. 2020;33(17):1230-1256. doi: 10.1089/ars.2019.7950.

17.   Datta S, Sinha D*. EGCG maintained Nrf2-mediated redox homeostasis and minimized etoposide resistance in lung cancer cells. J Func Foods. 2019; 62:103553. doi.org/10.1016/j.jff.2019.103553

18.   Prasad P, Vasas A, Hohmann J, Bishayee A, Sinha D*. Cirsiliol suppressed epithelial to mesenchymal transition in B16F10 malignant melanoma cells through alteration of PI3K/AKT/NF-κB signaling pathway. Int J Mol Sc. 2019; 20 (3):608.

19.   Das B, Sarkar N, Bishayee A, Sinha D*. Dietary phytochemicals in the regulation of epithelial to mesenchymal transition and associated enzymes: A promising anticancer therapeutic approach. Semin Cancer Biol. 2019; 56:196-218 doi: 10.1016/j.semcancer.2018.11.007.

20.   Das B and Sinha D*. Diallyl disulphide suppresses the canonical Wnt signaling pathway and reverses the fibronectin-induced epithelial mesenchymal transition of A549 lung cancer cells. Food Funct. 2019; 10(1):191-202.

21.   Sarkar N and Sinha D*. EGCG partially restored redox homeostasis in arsenite stressed keratinocytes. J Appl Toxicol. 2018; 38: 1071-1080.

22.   Sinha D*, Biswas J, Nabavi SM, Bishayee A. Tea phytochemicals for breast cancer prevention and intervention: From bench to bedside and beyond. Semin Cancer Biol. 2017; 46:33-54

23.   Prasad P and Sinha D*. Low-level arsenic causes chronic inflammation and suppresses expression of phagocytic receptors. Environ Sci Pollut Res. 2017; 24(12):11708-11721.

24.   Sinha D*, Sarkar N, Biswas J, Bishayee A. Resveratrol for breast cancer prevention and therapy: Preclinical evidence and molecular mechanisms. Semin Cancer Biol.  2016; 40-41:209-232.

25.   Dutta K, Prasad P, Sinha D*. Chronic low level arsenic exposure evokes inflammatory responses and DNA damage. Int J Hyg Environ Health. 2015; 218(6):564-74.

26.   Sinha D*, Dutta K, Ganguly KK, Biswas J, Bishayee A. A novel synthetic oleanane triterpenoid suppresses adhesion, migration and invasion of highly metastatic melanoma cells by modulating gelatinase signaling axis. Mol Carcinog. 2015 ;54(8):654-67.

27.   Mukherjee B, Bindhani B, Saha H, Sinha D*, Ray MR. Platelet hyperactivity, neurobehavioral symptoms and depression among Indian women chronically exposed to low level of arsenic. Neurotoxicology 2014, 45:159-67.

28.   Nanda DP, Dutta K, Ganguly KK, Hajra S, Mondal SS, Biswas J, Sinha D*. MMP-9 as a potential biomarker for carcinoma of oral cavity: a study in eastern India. Neoplasma 2014, 6 (6): 747-757.

29.   Das D, Bindhani B, Mukherjee M, Saha H, Biswas P, Dutta K, Prasad P, Sinha D*, Ray MR. Chronic low level arsenic exposure reduces lung function in male population without skin lesions. Int J Pub Health 2014; 59(4):655-663.

30.   Sinha D*, Biswas J, Bishayee A. Nrf2-mediated redox signaling in arsenic carcinogenesis: a   review. Archives of Toxicology 2013; 87(2):383-96

31.   Sinha D*, Biswas J, Sung B, Aggarwal BB, Bishayee A. Chemopreventive and chemotherapeutic potential of curcumin in breast cancer. Current Drug Targets. 2012; 13(14):1799-819.

 

Book chapter

1.       Saha P, Samanta A, Ghosh S, Chaudhuri R, Sinha D*. Regulation of cell death by cysteine proteases in breast cancer in Book “Handbook of proteases in cancer cellular and molecular aspects”. Eds Chakrabarti S; CRC Press 2024; e book ISBN: 9781003394716, pp:411-428

2.       Ghosh S, Saha P, Samanta A, Chaudhuri R, Sinha D*. Signal transduction and regulation of phospholipases during tumorigenic processes in Book “Vol 4: Phospholipases in physiology and pathology”; Eds Chakrabarti S; Elsevier 2022; Vol:4, pp: 329-347

3.       Ghosh S, Samanta A, Prasad P, Sinha D*. Therapeutic implications of long noncoding RNA in lung cancer in Book “Handbook of Oxidative stress”; Eds Chakrabarti S; Springer Nature 2021; doi.org/10.1007/978-981-16-1247-3_70-1

4.       Datta S, Saha P, Dey S, Sinha D *. Natural Products as Chemosensitizers for Adjunct Therapy in Cancer Management in Book “Pharmacotherapeutic Botanicals for Cancer Chemoprevention”; Eds; Kumar M, Sharma A, Kumar P; Springer Nature, 2020; pp:67-119.

5.       Datta S, Saha P, Sinha D *. Level of oxidative stress: A fate determiner for carcinogenesis and anti-carcinogenesis in eBook “Oxidative Stress and Natural Antioxidants,” for the book series “Bentham Briefs in Biomedicine & Pharmacotherapy”; Eds; Kaur P, Mehta RG, Robin, Thind TS, Arora S; Bentham Science Publishers, 2020; Vol:1, pp:1-53

6.       Sinha D and Ray MR. Health Effects of Indoor Air Pollution Due to Cooking with Biomass Fuel; Eds Robert SM et al in Studies on Experimental Toxicology and Pharmacology, Oxidative Stress in Applied Basic Research and Clinical Practice. Springer 2016; pp:267-302

*Corresponding author